Lanthanide-doped upconversion nanoparticles (UCNPs) are confirmed an excellent functional agent as the core scaffolds of core-shell materials with outstanding optical imaging property 8, 9. In order to design of multifunctional MOF-base nanocarriers for bioapplication, incorporating NPs with unique optical properties within MOFs is indeed an effective strategy. Serving as nanocarriers for guest molecules, iron (III) carboxylate MOFs display several fascinating features including high pore volume and tunable pore size for efficient payloads and unconspicuous burst effect of entrapped drugs 5, 6, a large variety of structural topologies and compositions for decorating the frameworks with functional groups or molecules 7. MIL-100, MIL-101 MIL = Materials of Institute Lavoisier), have potential applications in biomedicine due to their acceptable in vitro and in vivo toxicological results 2, 3, 4. In this field, nano-sized metal-organic frameworks (MOFs) based on iron (III) carboxylate materials with different compositions and structures (e.g. As a medical nanoplatform, the design of multifunctional NPs which could not only carry small drug molecules for therapeutics but also be imaging agents for detecting cancer at the molecular level, is still an open challenge.

Recently, the development of novel nanoparticles (NPs) with unique biological properties has spurred tremendous research interest in the field of nanomedicine 1.

Mof core shell structure nanoparticle